Abivax’s HIV cure candidate, ABX464, caused a significant drop in the viral reservoir over an extended period during a Phase IIa study.
French Biotech, Abivax, targets the immune system to cure viral diseases. The company has announced initial results from the first cohort of patients in its most recent Phase IIa trialtesting its potential HIV cure, ABX464. Initial results support the drug’s ability to significantly reduce the HIV reservoir over a 28-day period. The next cohort of patients has commenced dosing for a 3-month study, with results expected in early 2018.
Human Immunodeficiency Virus (HIV) is a devastating disease of the immune system. The virus infects immune cells, impairs their function and puts the individual at risk of nasty infections and cancers. ABX464 combats this using a new mechanism to inhibit HIV replication, that it is hoped will not lead to resistance.
Nine out of eleven patients in first study cohort completed the study, and eight of these showed decreased viral load between days 0 and 28. Two patients did not complete the study due to adverse effects, but these were quickly resolved.
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