• Modulating the Immune System

    A clinical-stage biopharmaceutical company leveraging from its multiple drug development platforms to treat patients with chronic inflammatory diseases, viral infections, and cancer.

  • ABX464

    Fighting Inflammatory Diseases

    Abivax’s lead candidate ABX464, a potent anti-inflammatory agent, is being tested in a Phase 2b clinical trial for its potential to bring clinical benefit to patients with ulcerative colitis, and potentially other inflammatory indications.

  • ABX196

    Tackling Cancer

    A small molecule agonist of invariant Natural Killer T-Cells (iNKT) is currently being tested in a Phase 1/2 clinical trial for treatment of hepatocellular carcinoma (HCC).

About Us

Abivax is developing therapies that modulate the body’s natural immune system machinery. A clinical-stage company, Abivax leverages its immune enhancing and antiviral platforms to develop drug candidates to treat chronic inflammatory diseases, viral diseases, and cancer.

Its lead clinical candidate, ABX464, has demonstrated strong clinical anti-inflammatory effects in ulcerative colitis.

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Pipeline

With four programs in clinical testing, a trial in Crohn’s disease to start and three projects in research and preclinical development, Abivax’s pipeline is strong and diversified, addressing many unmet needs.

Clinical Programs

  • ABX464 UC

    ABX464 is an oral, first-in-class, small molecule that has demonstrated safety and profound anti-inflammatory activity in preclinical trials and in Phase 2a and Phase 2b induction trials to treat ulcerative colitis (UC). Patients who completed the induction studies had the option to roll over into the respective open-label extension studies.

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  • ABX464 Rheumatoid Arthritis

    ABX464 is an oral, first-in-class, small molecule that has demonstrated safety and profound anti-inflammatory activity in the completed Phase 2a and Phase 2b induction studies as well as in long-term maintenance studies in patients with moderate-to-severe ulcerative colitis (UC) and rheumatoid arthritis (RA). In addition to the clinical observations in UC patients, Abivax generated excellent phase 2a clinical results in the RA induction and subsequent maintenance study after one year of treatment.

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  • ABX196 HCC

    ABX196 has been developed as a synthetic agonist of iNKT cells from a proprietary platform technology that identifies cells with immune enhancing potential in cancer models.

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  • ABX464 Crohn’s Disease

    ABX464 is an oral, first-in-class, small molecule that has demonstrated safety and profound anti-inflammatory activity in the completed Phase 2a and Phase 2b induction studies as well as in ongoing long-term maintenance studies in patients with moderate-to-severe ulcerative colitis (UC).
    Due to the clinical similarities of Crohn’s disease (CD) and UC, and the predictability of the DSS model for both UC and CD, several key opinion leaders (KOLs) are confident that ABX464 will also show beneficial effects in patients suffering from CD.

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R&D Assets

Science

Based on innovative research driven by the idea of modulating the body’s natural immune system mechanisms to cure diseases.

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News & Events

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Investors

Abivax SA has been listed on the Paris stock exchange since June 26, 2015.

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Symbol

ABVX

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