• Mobilizing the Immune System

    A clinical-stage biopharmaceutical company leveraging from its multiple drug development platforms to treat patients with inflammatory diseases, viral infections, and cancer.
  • ABX464

    Fighting Inflammatory Diseases

    Abivax’s lead candidate ABX464, a potent anti-inflammatory agent, is being tested in a Phase 2b clinical trial for its potential to bring clinical benefit to patients with ulcerative colitis, and potentially other inflammatory indications.
  • ABX464

    Developing a Functional Cure for HIV

    ABX464 is a Phase 2 candidate designed to functionally cure HIV by reducing the viral reservoir and is the first ever drug candidate to demonstrate this reduction in patients.
  • ABX196

    Tackling Cancer

    A small molecule agonist of invariant Natural Killer T-Cells (iNKT) is currently being tested in a Phase 1/2 clinical trial for treatment of hepatocellular carcinoma (HCC).

About Us

Abivax is developing therapies that stimulate the body’s natural immune system machinery. A clinical-stage company, Abivax leverages its immune enhancing and antiviral platforms to develop drug candidates to treat inflammatory diseases, HIV, and liver cancer.

Its lead clinical candidate, ABX464, has demonstrated the potential to treat inflammatory diseases and to reduce the viral reservoir in HIV.

Learn More View our Corporate Presentation

Abivax recently presented impressive results from its ABX464 maintenance study in ulcerative colitis at the United European Gastroenterology Conference, UEG Week 2019, in Barcelona, Spain on October 21, 2019. This data showed that impressive efficacy initially reported at 8 weeks after completion of the induction study is durable or improving at 12 months with ABX464. You can see documentation from these presentations here:

View Documentation

Pipeline

With four products in clinical testing, a trial in Crohn’s disease to start and three products in research and preclinical development, Abivax’s pipeline is strong and diversified, addressing many unmet needs.

Clinical Programs

  • ABX464 UC

    ABX464 is an oral, first-in-class, small molecule that has demonstrated safety and profound anti-inflammatory activity in preclinical trials and in a Phase 2a clinical trial, ABX464-101, to treat ulcerative colitis (UC). Patients who completed the induction study had the option to roll over into a 12-month open-label extension study, ABX464-102, in which 22 out of 23 eligible patients were enrolled.

    Read More
  • ABX464 Rheumatoid Arthritis

    ABX464 is an oral, first-in-class, small molecule that has demonstrated safety and profound anti-inflammatory activity in a completed Phase 2a induction study as well as a 12-month maintenance study in patients with moderate-to-severe ulcerative colitis (UC). In addition to the clinical observations in UC patients, Abivax generated promising pre-clinical data from collagen-induced arthritis animal models.

    Read More
  • ABX464 HIV

    ABX464 is an oral, first-in-class, novel, small molecule inhibiting HIV replication through an entirely new mechanism of action. For the first time in the treatment of HIV, this molecule could reduce or eliminate the viral reservoirs, and thus potentially deliver a long-lasting virological suppression in HIV-patients.

    Read More
  • ABX196 HCC

    ABX196 has been developed as a synthetic agonist of iNKT cells from a proprietary platform technology that identifies cells with immune enhancing potential in cancer models.

    Read More
  • ABX464 Crohn’s Disease

    ABX464 is an oral, first-in-class, small molecule that has demonstrated safety and profound anti-inflammatory efficacy in a completed Phase 2a induction study as well as a 12-month maintenance study in patients with moderate-to-severe ulcerative colitis (UC).
    Due the clinical similarities of Crohn’s disease (CD) and UC, and the predictability of the DSS model for both UC and CD, several key opinion leaders (KOLs) are confident that ABX464 will also show beneficial effects in patients suffering from CD.

    Read More

Science

Based on innovative research driven by the idea of stimulating the body’s natural immune system mechanisms to cure diseases.

Read More

News & Events

View More

Investors

Abivax SA has been listed on the Paris stock exchange since June 26, 2015.

View More

Symbol

ABVX