Pipeline

Product Development Portfolio

Inflammation

  • Ulcerative Colitis Anti-inflammatory
    • Research
    • Preclinical
    • Phase 1
    • Phase 2
    • Phase 3
    ABX464 Phase 2a complete; Phase 2b ongoing

    Description/Summary:

    ABX464 is an oral, first-in-class small molecule that has demonstrated anti-inflammatory activity in preclinical trials and shown impressive clinical safety and efficacy results in a Phase 2a proof of concept and in a Phase 2a 12-month maintenance study in patients with ulcerative colitis.

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    Milestones:

    • Phase 2a data from maintenance study reported in H2 2019
    • Phase 2b trial initiated
  • Crohn’s Disease Anti-inflammatory
    • Research
    • Preclinical
    • Phase 1
    • Phase 2
    • Phase 3
    ABX464 Phase 2b in preparation
  • Rheumatoid Arthritis Anti-inflammatory
    • Research
    • Preclinical
    • Phase 1
    • Phase 2
    • Phase 3
    ABX464 Phase 2a ongoing

Antiviral

  • HIV Lasting viral remission
    • Research
    • Preclinical
    • Phase 1
    • Phase 2
    • Phase 3
    ABX464 Phase 2a complete; Phase 2b in preparation

    Description/Summary:

    ABX464 is an oral, first-in-class, novel, small molecule inhibiting HIV replication through an entirely new mechanism of action. For the first time in the treatment of HIV, this molecule could reduce or eliminate the viral reservoirs, and thus potentially deliver a long-lasting virological suppression in HIV-patients.

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    Milestones:

    • Phase 2a data delivered in H1 2018
    • Initiation of Phase 2b trials in H1 2019
  • Ebola Polyclonal antibodies
    • Research
    • Preclinical
    • Phase 1
    • Phase 2
    • Phase 3
    ABX544
  • Respiratory Syncytial Virus Antiviral drug
    • Research
    • Preclinical
    • Phase 1
    • Phase 2
    • Phase 3
  • Dengue Antiviral drug
    • Research
    • Preclinical
    • Phase 1
    • Phase 2
    • Phase 3
  • Influenza Antiviral drug
    • Research
    • Preclinical
    • Phase 1
    • Phase 2
    • Phase 3

Cancer

  • Hepatocellular Cancer Immune Enhancer
    • Research
    • Preclinical
    • Phase 1
    • Phase 2
    • Phase 3
    ABX196 in Phase 1/2 POC clinical trial in HCC ongoing

    Description/Summary:

    ABX196 has been developed as a synthetic agonist of iNKT cells from a proprietary platform technology that identifies cells with immune enhancing potential in cancer models.

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    Milestones:

    • Phase 1/2 trial was initiated