Product Development Portfolio

Inflammation

  • Ulcerative Colitis Anti-inflammatory
    • Research
    • Preclinical
    • Phase 1
    • Phase 2
    • Phase 3
    ABX464 Phase 2b completed; Phase 3 to start in Q4 2021

    Description/Summary:

    ABX464 is an oral, first-in-class, small molecule that has demonstrated safety and profound anti-inflammatory activity in preclinical trials and in Phase 2a and Phase 2b induction trials to treat ulcerative colitis (UC). Patients who completed the induction studies had the option to roll over into the respective open-label extension studies.

    Read More

    Milestones:

    • Phase 2a data from 12- and 24-months maintenance study reported
    • Phase 2b data from induction study reported
  • Rheumatoid Arthritis Anti-inflammatory
    • Research
    • Preclinical
    • Phase 1
    • Phase 2
    • Phase 3
    ABX464 Phase 2a ongoing (patient recruitment completed)

    Description/Summary:

    ABX464 is an oral, first-in-class, small molecule that has demonstrated safety and profound anti-inflammatory activity in the completed Phase 2a and Phase 2b induction studies as well as in ongoing long-term maintenance studies in patients with moderate-to-severe ulcerative colitis (UC). In addition to the clinical observations in UC patients, Abivax generated promising pre-clinical data from collagen-induced arthritis animal models.

    Read More

    Milestones:

    • Phase 2a study ongoing
  • Crohn’s Disease Anti-inflammatory
    • Research
    • Preclinical
    • Phase 1
    • Phase 2
    • Phase 3
    ABX464 Phase 2b/3 pivotal study in preparation

    Description/Summary:

    ABX464 is an oral, first-in-class, small molecule that has demonstrated safety and profound anti-inflammatory activity in the completed Phase 2a and Phase 2b induction studies as well as in ongoing long-term maintenance studies in patients with moderate-to-severe ulcerative colitis (UC).
    Due to the clinical similarities of Crohn’s disease (CD) and UC, and the predictability of the DSS model for both UC and CD, several key opinion leaders (KOLs) are confident that ABX464 will also show beneficial effects in patients suffering from CD.

    Read More

Antiviral

  • Respiratory Syncytial Virus Antiviral drug
    • Research
    • Preclinical
    • Phase 1
    • Phase 2
    • Phase 3
  • Dengue Antiviral drug
    • Research
    • Preclinical
    • Phase 1
    • Phase 2
    • Phase 3
  • Influenza Antiviral drug
    • Research
    • Preclinical
    • Phase 1
    • Phase 2
    • Phase 3

Cancer

  • Hepatocellular Cancer Immune Enhancer
    • Research
    • Preclinical
    • Phase 1
    • Phase 2
    • Phase 3
    ABX196 in Phase 1/2 POC clinical trial in HCC ongoing

    Description/Summary:

    ABX196 has been developed as a synthetic agonist of iNKT cells from a proprietary platform technology that identifies cells with immune enhancing potential in cancer models.

    Read More

    Milestones:

    • Phase 1/2 trial ongoing